Acute Interstitial Nephritis Associated with Sofosbuvir and Daclatasvir
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منابع مشابه
Acute Interstitial Nephritis Associated with Sofosbuvir and Daclatasvir
Although new heptatis C virus treatments have increased efficacy and improved safety profiles, they also come with risk. We describe a 66-year-old white man with Child-Pugh A cirrhosis secondary to heptatis C virus genotype 3, who suffered from an acute kidney injury after treatment with sofosbuvir and daclatasvir. Kidney biopsy demonstrated evidence of acute tubular interstitial nephritis cons...
متن کاملSofosbuvir and daclatasvir
After entering hepatocytes, the viral genome of the hepatitis C virus (HCV) is translated into a single polypeptide. This polypeptide is subsequently cleaved into viral proteins, including non-structural (NS) proteins NS3, NS4A, NS5B and NS5B RNA dependent RNA polymerase (Figure 1) [3, 4]. These viral proteins are essential for viral replication and assembly making them significant targets for ...
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ژورنال
عنوان ژورنال: ACG Case Reports Journal
سال: 2017
ISSN: 2326-3253
DOI: 10.14309/crj.2017.84